Stereoselective synthesis and acaricidal activity of novel thiazolidinones
1991
Kasahara, I. | Matsui, N. | Yamada, T. | Kaeriyama, M. | Ishimitsu, K.
Hexythiazox, trans-5-(4-chlorophenyl)-N-cyclohexyl-4 methyl-2-oxothiazolidine-3-carboxamide, is a new potent acaricide which has a unique thiazolidinone structure. It has broad acaricidal spectrum and excellent ovicidal, larvicidal and nymphcidal action. Its synthesis requires stereoselective processes because the trans configuration at positions 4- and 5- in the thiazolidinone structure is essential for acaricidal activity. We have studied the stereoselective synthesis of phenylpropanolamines as key-intermediates of hexythiazox derivatives and established the novel stereoselective synthetic methods for trans thiazolidinones from phenylpropanolamines.
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