Shape of sweet receptors studied by computer modeling
1991
Rohse, H. | Belitz, H.D.
General models for sweeteners have been developed using a molecule building program by superimposition of the e/n-systems of a large number of sweet and nonsweet compounds from diverse structural classes. The models are based on psychophysical data (sweet thresholds) and clearly show the possible dimensions of the molecules compatible with sweet taste. The sweet potency depends strongly on the location of hydrophobic groups within the given sweet space. The models include amino acids, oxathiazione dioxides, benzisothiazolone dioxides, carboxyalkylbenzamides, naphthoimidazoles and related compounds.
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