A Rigid Bicyclic Platform for the Generation of Conformationally Locked Neuraminidase Inhibitors
2012
Brant, Michael G. | Wulff, Jeremy E.
Rapid mutation of the influenza virus through genetic mixing raises the prospect of new strains that are both highly transmissible and highly lethal, and which have the ability to evade both immunization strategies (through mutation of hemagglutinin) and current therapies (through mutation of neuraminidase). Inspired by a need for next-generation therapeutics, a synthetic strategy for a new class of rigid, bicyclic inhibitors of influenza neuraminidase is reported.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
Organic letters
ISSN
1523-7052
出版者
American Chemical Society
其它主题
Sialidase; Influenza
语言
英语
许可
//data.crossref.org/schemas/AccessIndicators.xsd:license_ref>http://purl.org/eprint/accessRights/OpenAccess | //data.crossref.org/schemas/AccessIndicators.xsd:program>//data.crossref.org/schemas/AccessIndicators.xsd:license_ref> | //data.crossref.org/schemas/AccessIndicators.xsd:program>
类型
Text; Journal Article
2024-02-27
MODS
