Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis

Iqbal, Naeem; Choi, Sungkyu; Kim, Eunjin; Cho, Eun Jin

Trifluoromethylation of Alkenes by Visible Light Photoredox Catalysis

2012

Iqbal, Naeem | Choi, Sungkyu | Kim, Eunjin | Cho, Eun Jin

A method for trifluoromethylation of alkenes has been developed employing visible light photoredox catalysis with CF₃I, Ru(Phen)₃Cl₂, and DBU. This process works especially well for terminal alkenes to give alkenyl-CF₃ products with only E-stereochemistry. The mild reaction conditions enable the trifluoromethylation of a range of alkenes that bear various functional groups.

显示更多 [+]