The reductive cleavage of picolinic amides
2016
O’ Donovan, Daniel H. | De Fusco, Claudia | Spring, David R.
Treatment of picolinic amides with excess zinc in aqueous hydrochloric acid at room temperature affords the corresponding amines in good to excellent yields. The mild reaction conditions exhibit useful functional group tolerance and facilitate the application of the picolinic amide moiety as a protecting group which can be easily introduced and selectively removed.
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书目信息
出版者
Oxford, UK : Blackwell Publishing Ltd
其它主题
Picolinic amides; Amide cleavage; Protecting groups; Ambient temperature; C–h activation
语言
英语
类型
Journal Article; Text
2024-02-27
MODS