Three new triterpenoids from Panax ginseng exhibit cytotoxicity against human A549 and Hep-3B cell lines

Ma, Hai-Ying; Gao, Hui-Yuan; Huang, Jian; Sun, Bo-hang; Yang, Bo

Three new triterpenoids from Panax ginseng exhibit cytotoxicity against human A549 and Hep-3B cell lines

2012

Ma, Hai-Ying | Gao, Hui-Yuan | Huang, Jian | Sun, Bo-hang | Yang, Bo

Three new triterpenoid derivatives, 3-O-β-D-glucopyranosyl-20(S)-protopanaxtriol (1), 3-formyloxy-20-O-β-D-glucopyranosyl-20(S)-protopanaxtriol (2) and 26-hydroxyl-24(E)-20(S)-protopanaxtriol (3), along with six known ginsenosides, were isolated from leaves of Panax ginseng. Their structures were established on the basis of spectral analysis (IR, 1D and 2D NMR, HRESI-MS). Compounds 1–3 exhibited various degree of cytotoxicity towards human A549 pulmonary carcinoma cells and Hep3B hepatoma cells.

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