Synthesis of aryl alkynyl carboxylic acids and aryl alkynes from propiolic acid and aryl halides by site selective coupling and decarboxylation
2012
Park, Kyungho | Palani, Thiruvengadam | Pyo, Ayoung | Lee, Sunwoo
The coupling of propiolic acid with aryl iodides afforded the aryl alkynyl carboxylic acids and aryl alkynes in generally good yields. Aryl alkynyl carboxylic acids were obtained when the reaction was performed in the presence of Pd(PPh₃)₂Cl₂ (2.5mol%), dppb (5.0mol%) and DBU (5equiv) at 50°C. For the synthesis of the terminal aryl alkynes, the reaction was conducted in the presence of Pd(PPh₃)₂Cl₂ (2.5mol%), dppb (5.0mol%), DBU (5.0equiv), and Cu(acac)₂ (10mol%) at 25°C for 5h, and further reacted at 60°C for 6h.
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书目信息
出版者
The Royal Society of Chemistry
其它主题
Alkynes
语言
英语
类型
Journal Article; Text
2024-02-27
MODS