Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants
1995
Salah, N. | Miller, N.J. | Paganga, G. | Tijburg, L. | Bolwell, G.P. | Rice-Evans, C.
The purpose of this investigation was to establish the relative antioxidant activities in vitro of the flavanolic polyphenols, the catechins, and catechin-gallate esters. The relative antioxidant potentials were measured against radicals generated in the aqueous phase and against propagating lipid peroxyl radicals. The results show that in the aqueous phase their order of effectiveness as radical scavengers is epicatechin gallate (ECG) > epigallocatechin gallate (EGCG) > epigallocatechin (EGC) > gallic acid (GA) > epicatechin approximately equal to catechin; against propagating lipid peroxyl radical species, epicatechin and catechin are as effective as ECG and EGCG, the least efficacious being EGC and GA. This is consistent with their relative abilities to protect against consumption of LDL alpha-tocopherol. The results are discussed in the context of the most relevant antioxidant constituents of green tea extracts.
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