Synthesis, structure and DNA binding studies of 1,4-bis((4-nitrophenoxy)methyl)benzene and its reduction derivative
2011
Ḥaider, ʻAli | Akhter, Zareen | Jabeen, Fariya | Janjua, Naveed Kausar | Bolte, Michael
The dinitrocompound, 1,4-bis((4-nitrophenoxy)methyl)benzene (NMB) and its derivative 1,4-bis((4-aminophenoxy)methyl)benzene (AMB), a potential monomer for polymeric materials have been synthesized and characterized by elemental and spectral studies. AMB was also characterized by single crystal analysis as the monoclinic space group C2/c with unit cell parameters a=40.858(6)Å, b=5.4606(8)Å, c=7.7741(15)Å; α=90°, β=100.471(7)°, γ=90° and Z=4. The molecule is located on a centre of inversion and the water molecule on a twofold rotation axis. The cyclic voltammetric (CV) investigations showed the precursor and its amino-analogue to be strong ds.DNA binder and replication quencher. The threading intercalation mode of binding is proposed on the basis of positive peak potential shift and molecular structures.
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