Solvent-Directed Click Reaction between Active Methylene Compounds and Azido-1,3,5-triazines
2019
Yan, Ziqiang | Li, Yuanheng | Ma, Mingming
A novel solvent-directed click reaction between active methylene compounds and azido-1,3,5-triazines has been developed. In aqueous solution, the regiospecific trisubstituted 1,2,3-triazole products are quickly synthesized in high yields under mild conditions and easy to separate without column chromatography. This click reaction is controlled by the protonation of a nitrogen anion intermediate, and the postulated mechanism is substantiated by DFT calculations.
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书目信息
Organic letters
ISSN
1523-7052
出版者
Springer-Verlag
其它主题
Aqueous solutions; Protonation; Regioselectivity
语言
英语
类型
Journal Article; Text
2024-02-27
MODS