3-epi-Waol A and Waol C: polyketide-derived γ-lactones isolated from the endophytic fungus Libertella blepharis F2644
2015
Adames, Itzel | Ortega, Humberto E. | Asai, Yumi | Kato, Masaki | Nagaoka, Kazuya | TenDyke, Karen | Yongchun Shen, Young | Cubilla-Ríos, Luis
Two new γ-lactones, 3-epi-Waol A (1), and Waol C (2) were isolated, together with three known compounds [1-hydroxy-6-methyl-8-hydroxymethylxanthone, pestacin, and isopestacin], from the solid culture of the endophytic fungus Libertella blepharis that had been isolated from the mature leaf of Olyra latifolia, collected in the province of Colon, Republic of Panama. Elucidation of their structure was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. 3-epi-Waol A (1) showed a growth inhibition with IC50 values of 22.71μM against the parasite Trypanosoma cruzi; and 22.46, 6.20, and 1.0μM against MCF-7, HCT116, and H460 cancer cell lines, respectively.
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