Acylated triterpene saponins from Silene jenisseensis
1995
Lacaille-Dubois, M.A. | Hanquet, B. | Cui, Z.H. | Lou, Z.C. | Wagner, H.
From the roots of Silene jenisseensis a new trans-p-methoxycinnamoyl triterpene saponin has been isolated along with its cis-p-methoxycinnamoyl isomer as an inseparable mixture. Their structures were established by chemical means and spectroscopic methods including 1D- and 2D-homonuclear and heteronuclear correlation NMR spectroscopy as 3-O-[beta-D-galactopyranosyl-(1 leads to 2)-beta-D-glucuronopyranosyl]-28-O-[beta-D-glucopyranosyl (1 leads to 2)-alpha-L-rhamnopyranosyl-(1 leads to 2)-beta-D-4-O-trans-p-methoxycinnamoyl-fucopyranosyl] quillaic acid and its cis-isomer, respectively. They did not show any activity in the in vitro chemoluminescence granulocytes assay, but exhibited only a weak inhibitory effect in the cyclooxygenase inhibition assay.
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