Usneaceratins A and B, two new secondary metabolites from the lichen Usnea ceratina
2022
Bui, Van Muoi | Huynh, Bui Linh Chi | Pham, Nguyen Kim Tuyen | Nguyễn, Ánh Tuyết | Nguyen, Thi Thuy Trang | Nguyen, Kim Phi Phung | Nguyễn, Tấn Phát
Two new compounds, comprising one dibenzofuran, named usneaceratin A (1), and one phenolic acid, named usneaceratin B (2), together with one known dibenzofuran, isousnic acid (3), and two known phenolics, orsellinic acid (4) and methyl orsellinate (5) were clarified from the lichen Usnea ceratina using variously chromatographic methods. Their structures were testified by comprehensive HR-ESI-MS, and NMR spectroscopic analysis, and comparison with published data. Their α-glucosidase inhibitory activity of all compounds was measured. Usneaceratin B (2) possessed better inhibition against α-glucosidase enzyme (IC₅₀ value of 41.8 μM) than the standard drug acarbose (IC₅₀ value of 214.50 μM).
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