Development of a reductive Hosomi-Sakurai reaction
2018
Bauer, Adriano | Maulide, Nuno
Herein we present a full account on the reductive Hosomi-Sakurai reaction along with some insight into the reaction mechanism. Stereoselectivity appears to be highest when the crucial carbocation intermediate, derived by protonation of the homoallylic ether, is sufficiently stabilized to ensure that the hydride transfer becomes rate-determining. This hypothesis is supported by experiment and mechanistic analysis.
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书目信息
出版者
Les conservatoire et jardin botaniques de la Ville de Genève (The Conservatory and Botanical Gardens of the City of Geneva)
其它主题
Reaction mechanisms; Metal free; Stereoselectivity; Hosomi-sakurai; Internal redox; Hydride transfer acetal; Protonation; Hydrides
语言
英语
注释
Pre-press version
类型
Journal Article; Text
2024-02-27
MODS