Surface patterned hydrogel film as a flexible scaffold for 2D and 3D cell co-culture

Zhu, Feiyan; Chen, Ying; Yang, Saina; Wang, Qian; Liang, Fuxin; Qu, Xiaozhong; Hu, Zhongbo

Surface patterned hydrogel film as a flexible scaffold for 2D and 3D cell co-culture

2016

Herein we report a facile route for the preparation of surface patterned dynamic hydrogel films, which are not only a matrix to encapsulate one type of cell in 3D but also a substrate to support aligned aggregates of magnetic silica rods to adhere another type of cell in 2D. This enables the composite hydrogel films to be flexible scaffolds for engineering multi-cellular tissues.

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