Modular o-Quinone Catalyst System for Dehydrogenation of Tetrahydroquinolines under Ambient Conditions
2014
Wendlandt, Alison E. | Stahl, Shannon S.
Quinolines are common pharmacophores present in numerous FDA-approved pharmaceuticals and other bioactive compounds. Here, we report the design and development of new o-quinone-based catalysts for the oxidative dehydrogenation of tetrahydroquinolines to afford quinolines. Use of a Co(salophen) cocatalyst allows the reaction to proceed efficiently with ambient air at room temperature. The utility of the catalytic method is demonstrated in the preparation of a number of medicinally relevant quinolines.
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书目信息
出版者
Multidisciplinary Digital Publishing Institute
其它主题
Dehydrogenation; Ambient temperature
语言
英语
许可
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类型
Journal Article; Text
2024-02-27
MODS