Synthesis and gametocidal activity of 1-aryl-5-(aminocarbonyl)-1H-pyrazole-4-carboxylic acids
1992
Lynch, M.P. | Ackmann, S.A. | Heim, D.R. | Davis, G.E. | Staszak, M.A. | Beck, J.R. | Tschabold, E.E. | Wright, F.L.
A series of 1-aryl-5-(aminocarbonyl)-1H-pyrazole-4-carboxylic acids were serendipitously discovered to be chemical hybridizing agents. Different synthetic routes were developed for the active analogs depending on whether an electron withdrawing group or electron donating group was present on the phenyl ring. Development of the "second generation gametocides" produced analogs which were 5-6 times more active than the original lead.
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书目信息
出版者
Elsevier Science
其它主题
Bioassays; Gametocides
语言
英语
注释
In the series analytic: synthesis and chemistry of agrochemicals iii / edited by d.r. baker, j.g. fenyes, and j.j. steffens.
类型
Journal Article; Text
2024-02-27
MODS