Synthesis and assessment of a maleimide functionalized BF₂ azadipyrromethene near-infrared fluorochrome

Wu, Dan; Cheung, Shane; Devocelle, Marc; Zhang, Li-Jun; Chen, Zhi-Long; O'Shea, Donal F.

Synthesis and assessment of a maleimide functionalized BF₂ azadipyrromethene near-infrared fluorochrome

2015

The first water soluble maleimide bearing NIR BF₂-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(β-A)SKKKKTKV-NH₂ and a thiol substituted cRGD. NIR fluorescence imaging showed rapid cellular delivery of the CPP conjugate and effective in vivo tumour localization for the cRGD conjugate.

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