The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

Bolt, C. E.; Davies, J. A.; Randall, S.; Skinner, G. R. B.

The influence of the milieu on the rate of neutralisation of herpes simplex virus 1

1998

Bolt, C. E. | Davies, J. A. | Randall, S. | Skinner, G. R. B.

The rate of neutralisation of herpes simplex virus 1 was increased by up to more than five hundred-fold when the virus suspension and antiserum were each diluted to one hundred-fold in water instead of phosphate buffered saline. This phenomenon, which was observed for two human positive sera and a rabbit purified polyclonal antibody, may represent an unrecognised homeostatic mechanism where neutralising antibody is ‘dilution-fast’ under physiological conditions of transudation or pathological conditions of inflammation.

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