Animal models of oxidative stress, aging, and therapeutic antioxidant interventions
2002
Melov, S.
Oxidative stress is a ubiquitous phenomena in all cell types, and it is primarily produced in mitochondria which are essential for multicellular life. Oxidative stress targets can be wide ranging and include nucleic acids and a variety of macromolecules. This review discusses the role of oxidative stress in the context of animal models, focusing in particular on animal models of aging, as well as the development of a new class of therapeutic small molecular weight antioxidants that have proven effective in extending the lifespan of a simple invertebrate nematode.
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书目信息
出版者
Elsevier B.V.
其它主题
Transgenic; Therapeutic use; Free radical scavengers
语言
英语
类型
Journal Article; Text
2024-02-27
MODS