Enantiomeric sensing and separation by nucleic acids
2020
Oukacine, Farid | Ravelet, Corinne | Peyrin, Eric
Naturally occurring polymers (and their derivatives) such as polysaccharides and proteins are very popular chiral selectors in analytical sciences. In contrast, nucleic acids have received much less attention in the enantiomeric analysis field. However, some significant advances have been accomplished during the last thirty years. The present review covers these different contributions in the development of both chiral sensor and separation systems. They rely on the use of either nonspecific nucleic acid molecules or target-specific oligonucleotides. The main practical factors as well as the applicability features of the reported nucleic acid-based enantioselective tools are summarized. Some possible routes for improvement are also suggested.
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