Beiträge zur Synthese von Cystinpeptiden, dargestellt am Beispiel der Totalsynthese von Humaninsulin* / Contributions to the Synthesis of Cystine Peptides Illustrated by the Total Synthesis of Human Insulin
2014
Kamber, Bruno
The formation of disulfide bonds in separate chemical steps in a cystine peptide containing several cystine residues is exemplified by the synthesis of human insulin. The synthetic methods which made this approach feasible were 1) the thiol-induced fragmentation of sulfenyl thiocarbonate derivatives and 2) the conversion of S-trityl- and S-acetamidomethyl cysteine peptides to cystine peptides by oxidation with iodine.
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书目信息
出版者
John Wiley & Sons, Ltd
其它主题
Disulfide bonds; Asymmetrical cystine peptides; Selective sulfur protection; Iodine oxidation; Human insulin
语言
英语
类型
Journal Article; Text
2024-02-28
MODS