Labordiagnostik von Kollagenosen unter besonderer Berücksichtigung neurologischer Manifestationen / Labaratory diagnosis of connective tissue diseases with a focus on neurological manifestations
2006
Jacobi, Christian | Wildemann, Brigitte
Connective tissue diseases (CTD) are systemic autoimmune diseases. The diagnosis is based on established clinical classification criteria in association with laboratory tests. Of important relevance is the detection of positive antinuclear antibodies by immunofluorescence (IFA) testing, followed by the measurement of ANA fine specificities measured with immunoblot or ELISA. Involvement of the central and peripheral nervous system occurs in up to 60% of patients with CTD. Some autoantibodies have been implicated as markers of neuropsychiatric manifestations and various parameters were assessed in the cerebrospinal fluid for their diagnostic implication in patients with central nervous system involvement. Thus far, a diagnostic gold standard for nervous system manifestations has not become available. In this review, we describe immunoserological markers and cerebrospinal fluid findings in CTD (systemic lupus erythematodes, Sjogren's syndrome, scleroderma, antiphospholipid syndrome, mixed connective tissue disease) and discuss their importance for diagnostic use.
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