Eleganketal A, a Highly Oxygenated Dibenzospiroketal from the Marine-Derived Fungus Spicaria elegans KLA03
2014
Luan, Yepeng | Wei, Hongjuan | Zhang, Zhenpei | Che, Qian | Liu, Yankai | Zhu, Tianjiao | Mándi, Attila | Kurtán, Tibor | Gu, Qianqun | Li, Dehai
Eleganketal A (1), a naturally occurring aromatic polyketide possessing a rare highly oxygenated spiro[isobenzofuran-1,3′-isochroman] ring system, was isolated from the fungus Spicaria elegans KLA03 by culturing it in a modified mannitol-based medium. The structure of 1 including the absolute configuration was determined by combining spectroscopic analysis, synthesis of the racemic permethylated analogue, chiral-phase HPLC separation, and TDDFT-ECD analysis.
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