Newly synthesized bolaamphiphiles from castor oil and their aggregated morphologies for potential use in drug delivery
2015
Ewonkem, Monique B. | Grinberg, Sarina | Lemcoff, Gabriel | Shaubi, Eleonora | Linder, Charles | Heldman, Eliahu
The present study focused on synthesizing bolaamphiphiles from the readily available and inexpensive castor oil, a vegetable oil, which contains about 90% of ricinoleic acid. Two classes of symmetric and asymmetric bolaamphiphiles with acetylcholine head groups were synthesized and characterized by spectroscopic analysis. These novel bolaamphiphilic compounds self-assemble in aqueous media to form stable cationic spherical nano-sized vesicles that are potential drug delivery systems.
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