Lupane, friedelane, oleanane, and ursane triterpenes from the stem of Siphonodon celastrineus Griff
2013
Kaweetripob, Wirongrong | Mahidol, Chulabhorn | Prawat, Hunsa | Ruchirawat, Somsak
Twenty-one triterpenes consisting of a lupane derivative, two friedelanes, an oleanane derivative, and 17 ursane-type triterpenoids, together with three known triterpenes, three sterols, a fatty acid, a sesquiterpene alkaloid, and a glycerol derivative, were isolated from the stem of Siphonodon celastrineus. Their structures were characterized by various spectroscopic techniques, as well as comparison with literature data. Twenty-seven metabolites of these were evaluated for cytotoxic activity against six human cancer cell lines. The biosynthetic formation of a 1,4-dioxane bridge is also discussed.
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