Influence of Dietary n-3 Polyunsaturated Fatty Acids on Plasma Lipemic Effect of Vitamin B<sub>6</sub> Deficiency
1999
Bergami, R. | Maranesi, M. | Marchetti, M. | Sangiorgi, Z. | Tolomelli, B.
Since many connections exist between vitamin B<sub>6</sub> and lipid metabolism, we aim to investigate the lipemic effect of different dietary intakes of polyunsaturated fatty acids in rats fed a vitamin B<sub>6</sub> deficient diet. Diets were either vitamin B<sub>6</sub> deficient (-B<sub>6</sub>) or vitamin B<sub>6</sub> sufficient, pair-fed to the deficient group (PF) and ad libitum (N). The diets were combined with normal lipid (LC: soya bean-coconut-palm oils) and fish oil (FO: soya bean – fish oil). The fish oil diet with sufficient vitamin B<sub>6</sub> content caused an increase in n-3 long chain polyunsaturated fatty acids and a decrease in arachidonic acid. In the -B<sub>6</sub> group fed a normal lipid diet, the arachidonic acid percentage decreased and the linoleic acid percentage increased; in the -B<sub>6</sub> group fed fish oil these changes in fatty acid composition, already consequent upon dietary intake of n-3 long chain polyunsaturated fatty acids, did not show further variations. In the dietary condition of vitamin B<sub>6</sub> deficiency, plasma cholesterol content increased in rats fed a lipid control diet, whereas no hypocholesterolemic effect was observed in those fed a fish oil diet. Plasma triglyceride contents were not influenced by dietary lipid quality because, in all conditions, the lower food intake of the PF groups caused a decrease and vitamin B<sub>6</sub> deficiency caused an elevation in triglyceride contents which reached those of the ad libitum groups. The study highlights the interaction between vitamin B<sub>6</sub> and polyunsaturated fatty acids and the opportunity of dietary intake of fish oil to counterbalance some effects of vitamin B<sub>6</sub> deficiency.
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