New type platforms for in vitro vaccine assembly
2015
Atabekov, J. G. | Nikitin, N. A. | Karpova, O. V.
Studying the structure of plant viruses and viral coat proteins along with the possibilities of their modification and structural remodeling is very important for the development of novel approaches to the design of biotechnological products, including those of medical use. Being nonpathogenic for mammals, in particular for humans, undoubtedly, make plant viruses advantageous for the development of new functional and biologically active materials, particularly, candidate vaccines. The present review focuses attention on characteristics and applying in biotechnology of spherical particles—the new type platforms generated by structural remodeling of plant viruses. Spherical particles do not have structural analogues among the icosahedral viruses and represent a new type of biogenic platforms. The assembly of the spherical particle–antigen immunogenic complexes in vitro bring in the possibilities of inexpensive and easy production of different vaccines.
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