Solvent-promoted catalyst-free N-formylation of amines using carbon dioxide under ambient conditions

Lv, Hui; Xing, Qi; Yue, Chengtao; Lei, Ziqiang; Li, Fuwei

Solvent-promoted catalyst-free N-formylation of amines using carbon dioxide under ambient conditions

2016

Lv, Hui | Xing, Qi | Yue, Chengtao | Lei, Ziqiang | Li, Fuwei

An unprecedented catalyst-free formylation of amines using CO₂ and hydrosilanes was developed. The solvent plays a vital role in promoting the interaction of amines with hydrosilanes and subsequent CO₂ insertion, thus facilitating the simultaneous activation of N–H and Si–H bonds. Based on relevant mechanistic studies, a plausible mechanism involving a silyl carbamate intermediate is proposed.

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