Mannan synthetase activity in three strains of Candida albicans
1988
Saxena, Ashima | Cihlar, Ronald L.
Mannan synthetase activity has been investigated in Candida albicans, strain 4918, as well as in two relatively avirulent, ceruleninâresistant mutant derivative strains, 4918â2 and 4918â10. In addition, investigations pertaining to the effects of the agents, cerulenin and sodium butyrate, on the level of mannan synthetase activity during the yeast to hyphal transition of these strains have been performed. The results show that mannan synthetase activity in yeast cells of both mutant strains is consistently higher than that observed in the parental strain. Similarly, the profile of enzyme activity exhibited by the mutant strains as morphogenesis proceeds differs from that of the wildâtype. Sodium butyrate has no significant effect on enzyme activity in these strains, but the presence of cerulenin results in alterations in mannan synthethase activity during morphogenesis of strain 4918.
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