Fate choice of post-natal mesoderm progenitors: skeletal versus cardiac muscle plasticity
2014
Costamagna, Domiziana | Quattrocelli, Mattia | Duelen, Robin | Sahakyan, Vardine | Perini, Ilaria | Palazzolo, Giacomo | Sampaolesi, Maurilio
Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
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