Bisacremines E–G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105

Wu, Ping; Xue, Jinghua; Yao, Lei; Xu, Liangxiong; Li, Hanxiang; Wei, Xiaoyi

Bisacremines E–G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105

2015

Three dimeric acremines, bisacremines E–G (1–3), with an unusual carbon skeleton were isolated from cultures of the soil-derived fungus Acremonium persicinum SC0105. Their structures were elucidated by spectroscopic analysis, X-ray diffraction, and ECD/TDDFT computations. Compound 3 exhibited inhibitory effects on the production of TNF-α, IL-6, and NO in LPS-stimulated macrophages. A biogenetic pathway with a [4 + 2] cycloaddition as the key reaction is proposed for 1–3.

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