Miniaturized biochemical sensing devices based on planar bilayer lipid membranes

Trojanowicz, M.

Miniaturized biochemical sensing devices based on planar bilayer lipid membranes

2001

Trojanowicz, M.

Methods of in-vitro artificial formation of bilayer lipid membranes (BLM) and their analytical applications are reviewed, on the basis of 122 literature references. Different techniques for preparation of free-suspended planar BLMs, and gel-, filter-, and solid-supported systems are presented. The analytical applications developed are based on direct interaction of analytes with chemically unmodified BLMs, and with systems modified by use of redox mediators, ionophores, ion-channel forming species, enzymes, antibodies, or DNA.

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