Synergistic Pd/Enamine Catalysis: A Strategy for the C–H/C–H Oxidative Coupling of Allylarenes with Unactivated Ketones

Tang, Shan; Wu, Xudong; Liao, Wenqing; Liu, Kun; Liu, Chao; Luo, Sanzhong; Lei, Aiwen

Synergistic Pd/Enamine Catalysis: A Strategy for the C–H/C–H Oxidative Coupling of Allylarenes with Unactivated Ketones

2014

By combining catalytic nucleophilic enamine activation with Pd-catalyzed C–H activation of allylarenes, the first oxidative allylic alkylation of unactivated ketones was achieved. Mechanistically, the Pd-catalyzed allylic C–H activation and proline-catalyzed ketone nucleophilic activation worked synergistically for the oxidative cross-coupling between allylarenes and unactivated ketones.

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