The ionic response of the liver fluke, Fasciola hepatica to ouabain, monensin and the deacetylated (amine) metabolite of diamphenethide
1991
Caseby, R.H. | Fairweather, I. | Harriott, M.
The ionic response of the liver fluke, Fasciola hepatica to perturbation of Na,K-pump activity has been determined by atomic absorption spectrophotometry. The Na+/K+/-ATPase inhibitor ouabain (1 X 10(-4) M) induced a marked reduction in K+ levels; Na+ and Ca2+ levels also fell. The sodium ionophore monensin (1 X 10(-4) M) also caused a decrease in K+ levels, to below that of Na+. Brief pretreatment with ouabain (1 X 10(-4) M, 15 min) followed by monensin treatment did not affect the decline in K+ levels, but did prevent the short-lived Na+ decline observed with monensin alone. The deacetylated (amine) metabolite of the fasciolicide diamphenethide caused a short-lived drop in Na+ levels, but otherwise produced little change in ion levels within the fluke.
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