Saved by the Matrix: UPR Independent Survival under ER Stress

Koopman, Mandy; Hetz, Claudio; Nollen, Ellen A.A.

Saved by the Matrix: UPR Independent Survival under ER Stress

2019

Koopman, Mandy | Hetz, Claudio | Nollen, Ellen A.A.

Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.

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