Effects of quantity and unsaturation of dietary fat on serum components in normal and diabetic Macaca nigra
1979
Howard, Charles F., Jr
Dietary fat affects serum lipids independently of dietary cholesterol. Normal and diabetic monkeys were fed cereal-based diets with either a low fat (LF = 2.5%) or a higher fat (13.2%) content; the latter had varying concentrations of safflower and coconut oil to attain greater polyunsaturation (SFO) or saturation (CCO) in the diets. Dietary cholesterol was less than 0.01%. Serum triglyceride concentrations were greatest when monkeys consumed the LF (higher carbohydrate) diet and lowest when they consumed the SFO diet. Concentrations were greater in diabetic than in normal monkeys fed the LF and SFO diets but both had similar concentrations when fed the CCO diet. Cholesterol levels in diabetic monkeys were only slightly higher than normals regardless of diet. In both groups, triglyceride concentrations correlated significantly with very-low-density-lipoprotein, and cholesterol levels correlated with low-density-lipoprotein. Thus, the responses of the monkeys to dietary fat manipulation depend on both the diet fat content and composition as well as the normal or diabetic metabolic state of each monkey.
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