Ytterbium-catalyzed synthesis of dihydropyridines

Sueki, Shunsuke; Takei, Ryo; Abe, Junya; Shimizu, Isao

Ytterbium-catalyzed synthesis of dihydropyridines

2011

Sueki, Shunsuke | Takei, Ryo | Abe, Junya | Shimizu, Isao

The reaction of anilines, benzaldehydes, and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)₃ proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields.

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