Preparation, Structure Elucidation, and Antiviral and Cytotoxic Activities of Acylation Derivatives of Cytochalasin B

Zhang, Xue-Qing; Guan, Fei-Fei; Li, De-Bao; Wang, Chang-Yun; Shao, Chang-Lun

Preparation, Structure Elucidation, and Antiviral and Cytotoxic Activities of Acylation Derivatives of Cytochalasin B

2017

Zhang, Xue-Qing | Guan, Fei-Fei | Li, De-Bao | Wang, Chang-Yun | Shao, Chang-Lun

Five acylation derivatives (1a–1e) were prepared by acylation of cytochalasin B (1), which was isolated from the marine-derived fungus Curvularia lunata. Compound 1 and its acylation derivatives 1a–1e were evaluated for their antiviral and cytotoxic activities in vitro. In particular, compound 1e exhibited potent antiviral activity against HSV and EV71 with IC₅₀ values of 29.5 and 21.4 μM, respectively, which were 4-fold and 11-fold stronger than that of the positive control, ribavirin.

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