A comparative study on the haemoglobin polymorphism of domestic sheep of the islands of Chios, Cyprus and Sardinia
1995
Hadjisterkotis, E. | Manca, L. | Naitana, S. | Masala, B.
Different alleles at the two linked alpha-globin loci are present in sheep: I alpha 113Leu and II alpha 113Leu, I alpha 8Ala,113Leu, I alpha 15Asp,113Leu, and II alpha 113His. Triplicated alpha-gene haplotypes are also common. Six different beta-globins (A, B, E, G, H, and I) contribute to the Hb polymorphism. A comparative study on the biochemical polymorphism of alpha- and beta-globins in pure sheep breeds of the Mediterranean islands of Chios, Cyprus, and Sardinia is described. Cyprus and Sardinia breeds have the lower frequency of alpha-globin variants. Chios sheep possess the high 0.40 frequency of the I alpha 8Ala,113Leu-II alpha 113His arrangement. No alpha-gene triplications were observed amongst Chios and Cyprus breeds. None showed the I alpha 15ASP,113Leu variant. The beta B allele largely predominates; the frequency of the beta A was lower (f = 0.03) amongst Sarda sheep that also possess the beta I variant. A novel beta B-globin variant was observed in the Chios breed. Both natural and artificial selection may be the cause for these differences.
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