A new polyhydroxylated oleanane triterpenoid from the roots of Rhodomyrtus tomentosa
2020
A new oleanane triterpenoid, 2α,3β,6β,23,29-pentahydroxyolean-12-en-28- oic acid (1), was isolated from the roots of Rhodomyrtus tomentosa, together with four known oleanane triterpenoids (2–5) and two known ursane triterpenoids (6–7). The structure of compound 1 was determined by extensive NMR and HR-ESI-MS data analysis. Compounds 4–5 showed cytotoxicity against PC12 cell lines at a concentration of 50 μM, and compound 1 exhibited moderate neuroprotective activity against corticosterone induced PC12 cell death at the same concentration.
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书目信息
出版者
Elsevier Ltd
其它主题
Oleanane triterpenoid; Neuroprotective activity; Rhodomyrtus tomentosa; Neuroprotective effect
语言
英语
注释
This work was supported by the National Natural Science Foundation of China [grant number 81703381], The Ph.D Start-up Fund of Natural Science Fundation of Guangdong Province, China [grant number 2017A030310531], and Guangdong Medical Science Foundation [grant number A2018203].
类型
Journal Article; Text
2024-02-28
MODS