Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids from Valeriana jatamansi
2012
Two new iridoids, jatadoids A (1) and B (2), and two known compounds (3 and 4) were isolated from Valeriana jatamansi. Their structures were elucidated on the basis of extensive spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D and 2D NMR). Compound 1 possessed an isovaleroxy group at the C-3 position that has previously been unreported in the class of iridoids. Four compounds were evaluated and compounds 1 and 3 showed moderate neuroprotective effects against MPP⁺-induced neuronal cell death in human dopaminergic neuroblastoma SH-SY5Y cells.
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书目信息
Bioscience, biotechnology, and biochemistry
卷
76
期
7
页码
1401
- 1403
ISSN
1347-6947
出版者
Elsevier Ltd
其它主题
Neuroprotective effect; Valeriana jatamansi; Neurons
语言
英语
注释
Nal-ap-2-clean
类型
Journal Article; Text
2024-02-28
MODS