A water-stable and biofriendly 2D anionic zinc(II) metal–organic framework for drug delivery
2018
A water-stable 2D Zn-based MOF with chemical formulae [(Me2NH2)4Zn2(FDC)4]n (1) (FDC = 2,5-furandicarboxylate) was synthesized and structurally characterized. TGA and PXRD results show high thermal and water stability for 1. 1 exhibits a 2D (4,4) net with 1D channel of 7.2 × 7.2 Ų along the c axis. Desolvated 1 adsorbs around 11.4 wt% 5-Fluorouracil and the cumulative release value of 5-Fluorouracil at 48 h was about 96.5% and 99% in PBS (pH = 7.4 and pH = 6.0) at 37 °C, respectively. The in vivo Zebrafish toxicity tests and in vitro MTT assays of 1 at different concentrations results reveal that 1 is nontoxic.
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