Stability of Bovine Spongiform Encephalopathy Prions: Absence of Prion Protein Degradation by Bovine Gut Microbiota
2012
Bovine spongiform encephalopathy (BSE) is transmitted by the oral route. However, the impacts of anaerobic fermentation processes in cattle on the stability of BSE‐associated prion protein (PrPSc) are still unresolved. In this study, experiments were designed to assess the ability of complex ruminal and colonic contents of bovines to degrade BSE‐derived PrPSc. No significant decrease in PrPSc levels in BSE brain homogenates was detected by Western blotting after up to 66 h of co‐incubation with intestinal fluids. These results indicate that BSE‐associated PrPSc survive gastrointestinal digestion processes in cattle and might be excreted via faeces.
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