Citrinin mycotoxicosis in Beagle dogs
1974
Carlton, W.W. | Sansing, G. | Szczech, G.M. | Tuite, J.
Three trials were completed in which young beagle dogs were either fed a citrinin-containing culture of Penicillium citrinum (Trial I) or were administered pure citrinin either i/p (Trial II) or orally (Trial III). Dogs fed the fungal culture and those given 20 or 40 mg pure citrinin/kg body weight developed renal disease. Dogs given 2.5 and 5 mg/kg remained clinically normal and without renal lesions. Clinicopathological evidence of renal damage included a rise in blood urea nitrogen, glucosuria, proteinuria, lowered urinary specific gravity, increased urinary activities of lactic dehydrogenase, glutamic-oxalacetic transaminase and isocitric dehydrogenase and the presence of numerous necrotic renal tubular epithelial cells in the urinary sediment. Emesis and intestinal intussusception occurred in the dogs given 20 or 40 mg/kg i/p. Renal lesions consisted of degeneration and necrosis of the tubular epithelium, most prominently in the thick segment of Henle and in the distal convoluted tubules.
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