GC-MS-FID and potentiation of the antibiotic activity of the essential oil of Baccharis reticulata (ruiz & pav.) pers. and α-pinene
2020
Freitas, Priscilla Ramos | de Araújo, Ana Carolina Justino | dos Santos Barbosa, Cristina Rodrigues | Muniz, Débora Feitosa | da Silva, Ana Cristina Albuquerque | Rocha, Janaína Esmeraldo | de Morais Oliveira-Tintino, Cícera Datiane | Ribeiro-Filho, Jaime | da Silva, Luiz Everson | Confortin, Camila | do Amaral, Wanderlei | Deschamps, Cícero | Barbosa-Filho, José Maria | de Lima, Natanael Teles Ramos | Tintino, Saulo Relison | Melo Coutinho, Henrique Douglas
The genus Baccharis (Asteraceae) demonstrated the presence of compounds with antibacterial, antifungal and antioxidant activities. Because of the increasing rates of antimicrobial resistance, adequate treatment of infections caused by Gram-negative bacteria has become challenging. The objective of the present study was evaluate the antibacterial and antibiotic-modifying activity of the essential oil obtained from Baccharis reticulata (Ruiz & Pav.) Pers. and the compound α-pinene against Pseudomonas aeruginosa and other multiresistant bacteria. An analysis by gas chromatography associated with mass spectrometry (GC/MS) revealed the presence of dilapiol (33.8 %), α-pinene (31.7 %) and β-pinene (9.4 %) as major components of the oil. The determination of the Minimum Inhibitory Concentration (MIC) revealed that the oil has antibacterial activity against S. aureus only. However, the oil potentiated the norfloxacin and gentamicin against all strains evaluated. Also, α-pinene increased the activity of norfloxacin against E. coli, as well as potentiated the activity of norfloxacin and gentamicin against S. aureus. Therefore, the authors conclude that the essential oil of B. reticulata, as well as the compound α-pinene, have antibacterial and antibiotic-modulating activities that make them useful in the development of new weapons against bacterial resistance.
显示更多 [+] 显示较少 [-]