Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice
2011
Morohoshi, Kazuki | Yoshida, Katsumi | Nakagawa, Yoshinori | Hoshikawa, Saeko | Ozaki, Hiroshi | Takahashi, Yurie | Itō, Sadayoshi | Mori, Kouki
We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto’s thyroiditis (HT). Am80 (0, 0.1 or 1mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.
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