Sinularioside, a triacetylated glycolipid from the Indonesian soft coral Sinularia sp., is an inhibitor of NO release
2012
Putra, Masteria Yunovilsa | Ianaro, Angela | Panza, Elisabetta | Bavestrello, Giorgio | Cerrano, Carlo | Fattorusso, Ernesto | Taglialatela-Scafati, Orazio
Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded a known glucosylcerebroside of the sarcoehrenoside-type and sinularioside (2), a new naturally triacetylated glycolipid containing two α-d-arabinopyranosyl residues and a myristyl alcohol unit. Their complete stereostructures were solved by interpretation of MS and NMR data along with CD analysis of degradation products. Sinularioside proved to moderately inhibit LPS-induced NO release, providing interesting clues into the poorly understood structure–activity relationships for anti-inflammatory glycolipids.
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