Machine learning-based prediction of toxicity of organic compounds towards fathead minnow
2020
Chen, Xingmei | Dang, Limin | Yang, Hai | Huang, Xianwei | Yu, Xinliang
Predicting the acute toxicity of a large dataset of diverse chemicals against fathead minnows (Pimephales promelas) is challenging. In this paper, 963 organic compounds with acute toxicity towards fathead minnows were split into a training set (482 compounds) and a test set (481 compounds) with an approximate ratio of 1 : 1. Only six molecular descriptors were used to establish the quantitative structure–activity/toxicity relationship (QSAR/QSTR) model for 96 hour pLC₅₀ through a support vector machine (SVM) along with genetic algorithm. The optimal SVM model (R² = 0.756) was verified using both internal (leave-one-out cross-validation) and external validations. The validation results (qᵢₙₜ² = 0.699 and qₑₓₜ² = 0.744) were satisfactory in predicting acute toxicity in fathead minnows compared with other models reported in the literature, although our SVM model has only six molecular descriptors and a large data set for the test set consisting of 481 compounds.
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