Growth and differentiation of regional adipose tissue: molecular and hormonal mechanisms
1991
Ailhaud, G. | Amri, E. | Bardon, S. | Barcellini-Couget, S. | Bertrand, B. | Catalioto, R.M. | Dani, C. | Doglio, A. | Forest, C. | Gaillard, D.
Growth of the various adipose depots has been shown in different animal species to respond differently according to age, diet and cold exposure. In humans, the differential capacity of various adipose depots to grow is a well-known observation for men and women but, at the cell level, it has become obvious that the irreversible acquisition of new fat cells is a continuous process throughout life, even into senescence. It is assumed that the differences in growth and differentiation between depots is due to a single event or combined events: (i) differences between depots are in the number of remaining adipose precursor cells able to respond to a given set of stimuli which are identical on a qualitative and quantitative basis; (ii) differences between depots are in the nature or concentration of some stimuli (locally produced) triggering or inhibiting growth and/or differentiation of adipose precursor cells: (iii) both phenomena are taking place.
显示更多 [+] 显示较少 [-]